My M/F OTP: Hmm. Honestly? Nine/Rose.
My M/M OTP: Nine/Jack
My F/F OTP: Amy/River Song
My endgame OTP: TARDIS/Doctor ;D
My original OTP: Nine/Rose, actually.
My crack OTP: Amy/Cleric Marco or possibly Eight/Rose
My guilty pleasure OTP: Eleven/Amy
My anti-OTP: Ten/Rose. I don't know why! The two of them just never did anything for me. And I really, really tried. *sighs*